The invention relates to a controlled-release formulation for preventing and/or treating sleep disorders comprising Zaleplon or a pharmaceutically acceptable salt thereof in immediate release form and Zolpidem or a pharmaceutically acceptable salt thereof in sustained release form, wherein Zaleplon or a pharmaceutically acceptable salt thereof and Zolpidem or a pharmaceutically acceptable salt thereof are released in two phases where the first phase is a immediate release phase of Zaleplon or a pharmaceutically acceptable salt thereof and the second phase is a sustained release phase of Zolpidem or a pharmaceutically acceptable salt thereof.本發明係關於一種用於預防及/或治療睡眠障礙之控釋調配物,其包含呈立即釋放形式之紮來普隆(Zaleplon)或其醫藥學上可接受之鹽及呈持續釋放形式之唑吡坦(Zolpidem)或其醫藥學上可接受之鹽,其中紮來普隆或其醫藥學上可接受之鹽及唑吡坦或其醫藥學上可接受之鹽分兩段式釋放,其中第一段為紮來普隆或其醫藥學上可接受之鹽的立即釋放期,且第二段為唑吡坦或其醫藥學上可接受之鹽的持續釋放期。(無元件符號說明)
