A fusion protein for inhibiting or preventing HPV infection diseases is disclosed, which comprises a peptide sequence of human papillomavirus type 16, a peptide sequence of binding and translocation, and a peptide within carboxyl terminal fragment. The present invention further comprising a composition of antibody, which conjugates to a fragment of E7 peptide or E6 peptide, wherein the nucleotide sequence of E7 peptide is shown as SEQ. ID. NO.1, and the nucleotide sequence of E6 peptide is shown as SEQ. ID. NO.3.本發明係有關於一種預防或抑制因人類乳突狀病毒16型所誘發疾病之融合蛋白，係包括：一段人類乳突狀病毒16型之蛋白胜肽片段；一段具有結合細胞以及移位功能之胜肽片段；以及一段具羧基終端部分之胜肽片段；其中，人類乳突狀病毒16型蛋白胜肽片段係E7蛋白胜肽片段或E6蛋白胜肽片段。本發明更揭示一種包含上述融合蛋白之醫藥組成物及與E7胜肽或E6胜肽結合之抗體組成物，其中E7胜肽之核苷酸序列為SEQ.ID.NO.1，E6蛋白胜肽之核苷酸序列為SEQ.ID.NO.3。
