The present invention relates to a multi anesthesia depth signal monitoring method, comprising 4 primary steps of: (1) physiological signals measuring step, (2) data analyzing step, (3) Indexation step, and (4) comprehensive-evaluating step. The monitoring method proposed by the present invention is able to provide three physiological indicators (including consciousness, ANS activity index and pain index) of anesthesia depth for doctors and medical professionals. Thus, the doctors and medical professionals can precisely predominate the patient’s clinical state, and then the patient would get the best anesthetic care, such that the medical incidents and disputes can be effectively reduced.本發明係關於一種多維麻醉深度信號監控方法,係包括4個主要步驟:(1)生理訊號擷取步驟、(2)資料分析步驟、(3)指數化步驟、以及(4)綜合評估步驟,其中,本發明之監控方法係可於手術中提供醫師與醫護人員在手術中同時監視病患之麻醉深度之三種生理指標變化(包含意識層次、自主神經反應及疼痛反應),以幫助醫師與醫護人員能更精確在臨床上判斷病人的狀態,可確保病患獲得最佳的麻醉照護,並減少醫療事故與糾紛。S1‧‧‧生理訊號擷取步驟S2‧‧‧資料分析步驟S3‧‧‧指數化步驟S4‧‧‧綜合評估步驟10‧‧‧腦電生理訊號11‧‧‧心電生理訊號12‧‧‧血氧生理訊號21‧‧‧經驗膜態分解22‧‧‧心率變異分析23‧‧‧心率間隙分析24‧‧‧脈波體積描記波形之振幅分析25‧‧‧專業醫療團隊作出之手術患者臨床狀況評估27‧‧‧自主神經活性分析26‧‧‧意識清晰度分析31‧‧‧意識清晰度指數28‧‧‧壓力疼痛分析32‧‧‧自主神經活性指數33‧‧‧壓力疼痛指數40‧‧‧歸納容錯模型