The invention relates to the use of inhibitors of IL-18 in the preparation ofa medicament for treatment and/or prevention of liver injury. The inventionfurther relates to the use of IL-18 inhibitors in the preparation of amedicament for treatment and/or prevention of arthritis, in particularrheumatoid arthritis. In addition to this, the invention relates to the use ofinhibitors of IL-18 in the preparation of a medicament for treatment and/orprevention of inflammatory bowel diseases, in particular of Crohn's diseaseand ulcerative colitis.