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雜環衍生物及其用途
- 专利权人:
- C&C RESEARCH LABORATORIES
- 发明人:
- KO, KWANG SEOK,高广硕,高廣碩,LEE, SOON OK,李顺玉,李順玉,KWON, YOUNG JIN,权永鎭,權永鎭,YUN, JEE HUN,尹智勳,CHO, NAM CHUL,赵南哲,趙南哲,LEE, JI EUN,李智恩,KIM,JUNG SOOK,金贞淑,金貞淑
- 申请号：
- TW108118749
- 公开号：
- TW202021969A
- 申请日:
- 2019.05.30
- 申请国别(地区):
- TW
- 年份:
- 2020
- 代理人:
- 摘要：
- The present invention relates to novel heterocyclic compounds useful in preparing drugs for the treatment of diseases associated with various functions of the histamine 4 receptor. Specifically, these drugs are useful in the prevention or treatment of inflammatory disorder, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itch skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, age-related macular degeneration, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (colitis, Crohn’s disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.本發明係有關於一種可用於製造與組織胺4受體的各項功能相關疾病之治療用藥物的新穎雜環化合物。特定言之，此等藥物可用於發炎病症、過敏、疼痛、鼻息肉、鼻炎、慢性鼻竇炎、鼻塞、鼻發癢、氣喘、慢性阻塞性肺疾、類風濕性關節炎、異位性皮膚炎、乾癬、濕疹、搔癢、皮膚癢、蕁麻疹、特發性慢性蕁麻疹、硬皮病、結膜炎、角膜結膜炎、眼內發炎、乾眼症、年齡相關性黃斑部退化、心臟功能失調、心律不整、動脈粥狀硬化、多發性硬化、發炎性腸病(結腸炎、克隆氏症、潰瘍性結腸炎)、發炎性疼痛、神經病變性疼痛、骨關節炎性疼痛、自體免疫性甲狀腺疾病、免疫媒介型(又稱第一型)糖尿病、狼瘡、術後沾黏、耳前庭病症、及癌症之預防或治療。
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
