BURKE, JAMES A,ORILLA, WERHNER C,LIU, HUI,DO, MARIANNE M,WHITCUP, SCOTT,HUGHES, PATRICK M,GHEBREMESKEL, ALAZAR N,XU, KUN,SPADA, LON T,ROBINSON, MICHAEL R
申请号：
NZ59529410
公开号：
NZ595294A
申请日:
2010.03.25
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
595294 Disclosed herein is a pharmaceutical composition comprising a plurality of sustained release biodegradable microspheres having a diameter between about 30 and about 100 microns, the microspheres comprising from about 10 to about 30 weight percent an anti-hypertensive agent, such as latanoprost, bimatoprost or travoprost, and from about 70 to about 90 weight % a biodegradable polymer, such as a polylactic polyglycolic copolymer (PLGA) and/or a poly lactic acid polymer (PLA), wherein the microspheres release therapeutically effective amounts of the anti-hypertensive agent for a period of time between about 10 days and about 120 days. Additionally disclosed is the use of said composition for treating elevated intraocular pressure comprise the step of intracameral administration of the medicament to a patient with elevated intraocular pressure.
