Blaquiere, Nicole,Do, Steven,Dudley, Danette,Folkes, Adrian J.,Goldsmith, Richard A.,Heald, Robert,Heffron, Tim,Kolesnikov, Aleksandr,Ndubaku, Chudi,Olivero, Alan G.,Price, Stephen,Staben, Steven,Wei,
申请号：
AU2010299820
公开号：
AU2010299820A1
申请日:
2010.09.27
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z is CR or N； Z is CR or N； Z is CR or N； Z is CR or N； and where (i) X is N and X is S, (ii) X is S and X is N, (iii) X is CR and X is S, (iv) X is S and Xis CR； (v) X is NR and X is N, (vi) X is N and Xis NR, (vii) X is CR and X is O, (viii) X is O and X is CR, (ix) X is CR and X is C(R), (x) X is C(R) and X is CR； (xi) X is N and X is O, or (xii) X is O and Xis N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for , and diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
