DERIVADOS DE (HETEROCICLO-PIPERIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA O DE (HETEROCICLO-PIRROLIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE P75
Refers to a compound of formula (i) where a is a group of formula (a) n is 1 or 2 M is 0 OR 1 W is a nitrogenous heterocycle as (b), among others R2 is a group of formula (c), among others X, x1 and x2 are O, C, N or s where at least one of them is different from a carbon Atom, R1 And R are independently h, halogen, among others and C, N,Among others, R7 and R8 are independently h, halogen, among others. R5 and R6 are H or alkyl of C1 - 6 1 - 2 represents 1 or 2. Preferred compounds are: 1 - (6,7 dihydro - 4H thieno [5] pyridin - 3.2 - C - yl) - 2 - [4 - (5 - fluoro - il - 2 - pyrimidin-2-yl) - BICYCLO [3.2 3.8 Grabarsky, ITs The Wrong Guy.Oct 1] - 3 - il - 6] ethanone acid - {(3S, 5R) - 3.5 - 4 - dimethyl - 2 - oxo - [2 - (phenyl - 6.7 - dihydro - 4 - tiazolo [5,4-c] pyridin - 5 - il) ethyl] - 1 - piperazin - il} - derivates, among others. It also relates to a Pharmaceutical Composition and a preparation proceimidento.This Compound is an inhibitor of neurotrophin receptor p75NTR, being useful for the treatment of diseases such as Alzheimers disease, depression, Schizophrenia, multiple sclerosisSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A ES UN GRUPO DE FORMULA (a) n ES 1 O 2 m ES 0 O 1 W ES UN HETEROCICLO NITROGENADO TAL COMO (b), ENTRE OTROS R2 ES UN GRUPO DE FORMULA (c), ENTRE OTROS X, X1 Y X2 SON O, C, N O S DONDE AL MENOS UNO DE ELLOS ES DIFERENTE DE UN ATOMO DE CARBONO R1 Y R SON INDEPENDIENTEMENTE H, HALOGENO, ENTRE OTROS Y ES C, N, ENTRE OTROS R7 Y R8 SON INDEPENDIENTEMENTE H, HALOGENO, ENTRE OTROS. R5 Y R6 SON H O ALQUILO C1-6 1-2 REPRESENTA 1 Ò 2. SON COMPUESTOS PREFERIDOS: 1-(6,7-DIHIDRO-4H-TIENO[3,2-c]PIRIDIN-5-IL)-2-[8-(5-FLUORO-PIRIMIDIN-2-IL)-3,8-DIAZA-BICICLO[3.2.1]OCT-3-IL]-ETANONA ACIDO 6-{(3S,5R)-3,5-DIMETIL-4-[2-OXO-2-(2-FENIL-6,7-DIHIDRO-4H-TIAZOLO[5,4-c]PIRIDIN-5-IL)-ETIL]-PIPERAZIN-1-IL}-NICOTINICO ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEIMIDENTO DE PREPARACION. DICHO COMPUESTO ES INHIBIDOR DEL RECEPTOR
