Process for producing 2- [4- (3- or 2-fluorobenzyloxy) benzylamino] propanamide having high purity

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专利权人:

ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー

发明人:

エレナ・バルバンテイ,ラウラ・フアラベツリ,パトリチア・サルバテイ,レナト・カネボツテイ,フランチエスコ・ポンツイーニ

申请号：

JP2014002958

公开号：

JP6023727B2

申请日:

2014.01.10

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C 1 -C 5 lower alkanols, allowing the formation and presence during a substantial position of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base into the same organic solvent.

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