Process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid

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专利权人:

Tangirala Prakasam

发明人:

Tangirala Prakasam,Borkatte Narasimha Hitesh Kumar,Sangu Perumal,Kothandapani Loganathan

申请号：

US13055472

公开号：

US08552030B2

申请日:

2009.07.03

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant.

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