PERILYL-DIHYDROPYRIMIDINONE HYBRID COMPOUNDS, PROCESS OF OBTAINING THE SAME AND USE IN THE PREPARATION OF MEDICINE TO TREAT CANCER AND DISEASES CAUSED BY Fungi
DENNIS RUSSOWSKY,MARCELO GONÇALVES MONTES D'OCA,VANESSA PEREIRA DE SOUZA,VINICIUS VENDRUSCULO
申请号：
BR102018073346
公开号：
BR102018073346A2
申请日:
2018.11.13
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention describes the synthesis of new hybrid perylyl-dihydropyrimidinones (per-dhpm) compounds connected by 1,2,3-triazole rings. specifically, the present invention comprises the multicomponent reaction pathway of biginelli and features biological antifungal activities and antiproliferative activities against cancer cell lines. the present invention is in the field of medicinal chemistry.a presente invenção descreve a síntese de novos compostos híbridos perilil-dihidropirimidinonas (per-dhpm) conectados por anéis 1,2,3-triazólicos. especificamente, a presente invenção compreende a via de reação multicomponente de biginelli e apresenta atividades biológicas antifúngicas e atividades antiproliferativas contra linhagens de células de câncer. a presente invenção se situa no campo da química medicinal.
