A clamping and ligating Device, comprising a ligation unit (10), a conveying unit (20), a protective sleeve (30), a connecting unit (40), a operation unit (50), and a traction unit (60) the connecting unit (40) connects the conveying unit (20) with the ligation unit (10), and can be disengaged to separate the conveying unit (20) from the ligation unit (10) the traction unit (60) controls the ligation unit (10) via push and pull movement the end of the traction unit (60) connected to the ligation unit (10) is breakable, so that the traction unit (60) can be broken away from the ligation unit (10) under a definite force the protective sleeve pipe (30) can accommodate the whole ligation unit (10) therein, thus, during endoscope penetration, avoiding the damage to the endoscope tube wall and the increase of penetration force.