Centro de Investigación y Desarrollo de los Medicamentos (CIDEM);Garcia Pupo, Laura;Nuñez Figueredo, Yanier;Tacoronte Morales, Juan Enrique;Verdecia Reyes, Yamila.;Ochoa Rodriguez, Estael
发明人:
申请号：
EP12821233.9
公开号：
EP2801581A1
申请日:
2012.12.27
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
This invention is related to chemistry and pharmacy and, in particular, to the production of novel molecular entities: esterane derivatives fused with spirostanes rings, acting upon the Central Nervous Systems (CNS).From diosgenin, a naturally occurring sapogenin, with some subsequent transformations thereof, spirosteroid derivatives of the I-IV general formula can be obtained, with a cyclopentaneperhydrophenantrene nucleus fused to a 25R-spirostanes nucleus.Such molecular entities have an anti-inflammatory and anti-glutamatergic actions that can be used to treat inflammatory, cerebrovascular, neurodegenerative, neuropsychiatric, and neurologic diseases.
