A physiological monitoring system may determine an equalized physiological signal. The system may receive a light signal that includes undesired signal features associated with a channel response. The system may equalize the light signal to mitigate the undesired signal features. The equalization may be performed on an analog signal or a digital signal. The equalization may include, for example, applying an inverse response of the channel response, such that undesired signal features are mitigated while signal features associated with a subject are retained. The equalization may be implemented with, for example, a finite impulse response filter.