Dpp-iv inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

FRIEDL THOMAS,BRAUN MICHAEL,EGUSA KENJI,MARUYAMA MEGUMI,NISHIOKA TAKAAKI,FUJITA HIKARU

申请号：

NZ61958009

公开号：

NZ619580A

申请日:

2009.04.02

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is a granulation liquid consisting of: a DPP-4 inhibitor, which has a free or primary amino group, namely 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine (Linagliptin / BI-1356) and L-arginine, a binder (preferably copovidone) and a solvent or mixture of solvents (preferably water). Also disclosed is the use of the granulation liquid as defined above for the preparation of granules comprising linagliptin, and metformin hydrochloride, L-arginine, a binder and a solvent filler.

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