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COMPOSES AYANT UNE ACTIVITE ANTIBACTERIENNE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT
专利权人:
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET);LABORATORIOS RICHMOND SOCIEDAD ANONIMA COMERCIAL INDUSTRIAL Y FINANCIERA
发明人:
BERTONCELLO, LUCILA,BURTON, GERARDO,DURAN, FERNANDO,MARTINEZ, MARIO,ZINI, ELVIRA,MORA MUNOZ, VERONICA
申请号:
CA2863221
公开号:
CA2863221C
申请日:
2013.01.10
申请国别(地区):
CA
年份:
2020
代理人:
摘要:
A compound of the structural formula I, a pharmaceutically acceptable salt,prodrug or derivative thereof,characterized in that R1 is selected from H, a linear or branched (C1-C5)alkyl group and a COR4 group; R2 is selected from H, a linear orbranched (C1-C5) alkyl group and a COR5 group; R3 is selected from H, a linearor branched (C1-C5) alkyl group, a linear orbranched (C1-C5)- O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an arylgroup, and an aryl (C1-C5) alkyl group wherein thearyl group can be an unsubstituted aryl or an aryl substituted with one ormore R6 groups and an NHCOR5 group, or the R2 and R3groups together with N may form a substituted or unsubstituted piperidine,morpholine or piperazine group; R4 is selected from Hand a (C1-C5) alkyl group; R5 is selected from an unsubstituted aryl group oran aryl group substituted with one or more R6, linear orbranched (C1-C5) alkyl or pyridyne groups and a pyridine group; R6 is selectedfrom (C1-C5) alkyl groups, halogen and nitro,provided that R1, R2 and R3 are not H atoms at the same time. The compoundspresent antibacterial activity. Process for theirpreparation and pharmaceutical compositions comprising them are alsodisclosed.
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