A syringe adapter includes a housing, a cannula having a first end and a second end with the second end of the cannula positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway with a membrane received by the passageway. The collet includes a locking member connected to the body of the collet. The membrane includes a body having a first end and a second end with the collet movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted. The passageway of the body of the collet includes a narrowed portion configured to compress a portion of the body of the membrane.
