A protective cover for use over a cast to prevent soiling of the cast from bodily fluids, excrement, etc. The cover remains on the cast until the cast is removed, but can be removed and replaced as needed. The protective cover is cleaned by wiping with a damp cloth or a disinfecting or soap wipe or solution. The material is soft and smooth to the skin and is hypoallergenic. The cover is in the shape of the cast with additional material provided at each of the cast openings so that the additional material can be tucked inside the cast. Depending on the shape of the cast, the cover may optionally be provided with a slit in the material to facilitate fitting it onto the cast. The slit is provided with fasteners on each side of the slit for securing the slit together to fit the cover over the cast.
