CONJUGUÉ ANTICORPS-MÉDICAMENT PRODUIT PAR LIAISON PAR L'INTERMÉDIAIRE D'UN LIEUR AYANT UNE STRUCTURE HYDROPHILE

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专利权人:

Limited;Daiichi Sankyo Company

发明人:

申请号：

EP13847461.4

公开号：

EP2910573A1

申请日:

2013.10.17

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH-(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.

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中国工程科技知识中心

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