The present invention relates to a composition comprising a zedoary extract as an effective ingredient for preventing, alleviating, or treating vasculitis. A zedoary extract according to the present invention exhibits the outstanding effect of suppressing high cholesterol diet-promoted plaque formation in blood vessels and lipid storage in the aorta, decreasing the expression of cathepsin in the aorta, suppressing expression of the vascular inflammation marker HMGB1, and suppressing the expression of vascular inflammation factors, so that the composition comprising a zedoary extract as an effective ingredient according to the present invention can be useful as a vasculitis therapeutic agent or a health functional food for preventing or alleviating vasculitis.
