A particle is composed of a solid center, which includes insoluble media, especially polyols, gomas, silicon derivatives, calcium or potassium, mineral compounds, such as phosphate, calcium and calcium carbonate, sucrose, cellulose derivatives, starch. The solid-state center is composed of one or more dyes, one or more metal pigments, one or more gas releasing compounds, such as sodium bicarbonate, sodium carbonate, potassium carbonate, and other substances that are optional, as well as one or more bitter agents, such as caffeine, Brucine, juna, quinine, etc.There are others Above the solid center are the active ingredients selected from anticoagulants and painkillers, such as morphine sulfate, oxycodone, methadone, tramadol, nabutin, etc.REFERIDA A UN GRANULO QUE COMPRENDE UN CENTRO SOLIDO QUE COMPRENDE SOPORTES INSOLUBLES, PARTICULARMENTE, POLIOLES, GOMAS, DERIVADOS DE SILICE, CALCIO O POTASIO, COMPUESTOS MINERALES TALES COMO FOSFATOS DICALCICOS, TRICALCICOS Y CARBONATOS DE CALCIO, SACAROSA, DERIVADOS DE CELULOSA, ALMIDON. DICHO CENTRO SOLIDO COMPRENDE ADEMAS, UNO O MAS COLORANTES, UNO O MAS PIGMENTOS METALICOS, UNO O MAS COMPUESTOS LIBERADORES DE GAS TALES COMO BICARBONATO SODICO, CARBONATO SODICO, BICARBONATO DE POTASIO, ENTRE OTROS Y OPCIONALMENTE, UNO O MAS AGENTES DE AMARGOR TAL COMO CAFEINA, BRUCINA, CUASINA, QUININA, ENTRE OTROS. SOPORTADO SOBRE EL CENTRO SOLIDO SE ENCUENTRA EL INGREDIENTE ACTIVO SELECCIONADO DE AGENTES ANTALGICOS Y ANALGESICOS TALES COMO SULFATO DE MORFINA, OXICODONA, METADONA, TRAMADOL, NALBUFINA, ENTRE OTROS
