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Novel Heterocyclic Derivatives
专利权人:
Novartis AG
发明人:
RADETICH, Branko,YU, Bing,ZHU, Yanyi
申请号:
ES12704135
公开号:
ES2611885T3
申请日:
2012.01.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the formula (I), or a pharmaceutically acceptable salt thereof: ** Formula ** wherein: X represents N or CH; R1 represents ** Formula ** wherein: R18 and R22 independently represent hydrogen, halogen, hydroxy, or hydroxy-alkyl of 1 to 3 carbon atoms; R19 and R21 independently represent hydrogen, amino, hydroxy, carboxy, alkoxy of 1 to 3 carbon atoms, amino-alkyl of 1 to 3 carbon atoms, alkyl of 1 to 3 carbon atoms-C (>; = O) -NH -, alkyl of 1 to 3 carbon atoms-S (>; = O) m-NH- or hydroxy-alkyl of 1 to 3 carbon atoms-; m represents 0, 1 or 2; R20 represents hydrogen, halogen or alkoxy of 1 to 3 carbon atoms; or R1 is selected from the group consisting of: wherein: R23 represents hydrogen or methyl; R24 represents hydrogen, oxo or alkyl of 1 to 3 carbon atoms; R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and R17 independently represent hydrogen or methyl; or R2 and R8 together form an ethylene bridge; or R2 and R6 together form a methylene bridge; or R12 and R14 together form an ethylene bridge; and Y represents O, CHR25 or CR26R27, wherein: R25 represents hydroxy or alkoxy of 1 to 3 carbon atoms; and R26 and R27 independently represent hydrogen or halogen; with the proviso that the compound of the formula (I) is different from 2,6-di-morpholin-4-yl-8-phenyl-9H-purine.Un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo:**Fórmula** en donde: X representa N o CH; R1 representa**Fórmula** en donde: R18 y R22 representan independientemente hidrógeno, halógeno, hidroxi, o hidroxi-alquilo de 1 a 3 átomos de carbono-; R19 y R21 representan independientemente hidrógeno, amino, hidroxi, carboxi, alcoxi de 1 a 3 átomos de carbono, amino-alquilo de 1 a 3 átomos de carbono, alquilo de 1 a 3 átomos de carbono-C(>;=O)-NH-, alquilo de 1 a 3 átomos de carbono-S(>;=O)m-NH- o hidroxi-alquilo de 1 a 3 átomos de carbono-; m representa 0, 1 o 2; R20 representa hidrógeno, halógeno o alcoxi de 1 a 3 átomos de carbono; o
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