PURPOSE: A pharmaceutical composition for nephritis prevention or treatment is provided to maximize treatment and prevention effects by multiply using each ingredient and to enhance safety by not generating any side effects. CONSTITUTION: A pharmaceutical composition for nephritis prevention or treatment comprises 30-45 parts by weight of Discoreae Rhizoma, 1-5 parts by weight of royal jelly, 50-69 parts by weight of honey as active ingredients. The health supplements for nephritis prevention or treatment comprises 30-45 parts by weight of Discoreae Rhizoma, 1-5 parts by weight of royal jelly, 50-69 parts by weight of honey as active ingredients. A manufacturing method of a pharmaceutical composition for nephritis prevention or treatment comprises the following steps: shattering Discoreae Rhizoma into pieces; mixing 1-5 parts by weight of royal jelly with 50-69 parts by weight of honey; and mixing 30-45 parts by weight of Discoreae Rhizoma powder into a mixture.본 발명은 신장염 예방 또는 치료용 조성물로, 산약, 로얄젤리 및 꿀을 혼합하였으므로 각각의 약리성분이 복합되어 이를 섭취시 신장염의 예방 또는 치료에 효과적이며, 체질에 관계없이 누구나 간편하게 복용이 가능하고 식품과 생약을 이용하여 제조하였으므로 인체에 부작용이 전혀 발생하지 않아 안전하고 용이하게 복용할 수 있다.