Systems and methods are disclosed for using an assessment of the quality of medical images of at least a portion of a patient's anatomy in order to automatically select, using a computer system, images to be used to produce models for a patient-specific simulation of blood flow. One method includes receiving one or more characteristics of accuracy, precision, or performance for a simulation of a patient's blood flow； receiving one or more images of at least a portion of a patient's anatomy； receiving an image quality score associated with the one or more images； and selecting, based on the received image quality score and the received one or more characteristics of accuracy, precision, or performance in performing the simulation, an image, of the one or more received images, to produce a model for use in the simulation of the patient's blood flow.
