The present invention relates to a de-noise system for 12-lead ECG, comprising: a device for processing transformation of stationary wavelet, extracts 12-lead ECG signal waveform from ECG instruments and transforms stationary wavelet into multiple-level detail functions a device for independent component analysis, separates 12-lead ECG signal waveform from noise and a device for processing transformation of reverse-wavelet, transforms reverse-wavelet into ECG waveform of the original time domain.本發明係關於一種12-導程心電圖去雜訊系統,其包含:一平穩小波轉換訊號處理之裝置,係可從心電圖儀器萃取出12-導程心電圖波形訊號,並利用平穩小波轉換成多階的細節函數;一獨立成份分析閥值選擇之裝置,係可透過獨立成份分析(ICA)將細節函數含有的雜訊及心電波形訊號分離;及一逆小波轉換訊號處理之裝置,係可利用逆小波轉換還原心電波形訊號為原時間域的心電波形訊號。10‧‧‧12-導程心電圖波形的萃取與解碼之裝置101‧‧‧XML檔案11‧‧‧平穩小波轉換訊號處理之裝置12‧‧‧獨立成份分析閥值選擇之裝置13‧‧‧逆小波轉換訊號處理之裝置141‧‧‧去雜訊後的12-導程心電圖波形