<;P>;PROBLEM TO BE SOLVED: To provide a new cyclic peroxide derivative having low cytotoxicity and high antimalarial activities, and capable of being synthesized in a short process. <;P>;SOLUTION: The cyclic peroxide derivative is represented by general formula (1) (wherein, X<;SP>;1<;/SP>;, X<;SP>;2<;/SP>;, R<;SP>;1<;/SP>;and R<;SP>;2<;/SP>;are each hydrogen or an arbitrary substituent). <;P>;COPYRIGHT: (C)2010,JPO&INPIT