ADAM CLARKE,ANTHONY DOYLE,COLLETTE BEHRENS,MATTHEW POLLARD,TERESA DOMAGALA
申请号：
BR112017008880
公开号：
BR112017008880A2
申请日:
2015.10.23
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention provides a fusion polypeptide comprising a first domain and a second domain, wherein the first domain comprises a polypeptide ligand which binds to a cell surface-associated antigen and the second domain comprises aglycosylated interferon &alpha； 2b (IFN&alpha；2b) having a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. The aglycosylated IFN&alpha；2b further comprises one or more amino acid substitutions or deletions which attenuate the activity of the aglycosylated IFN&alpha；2b.
