David L. Ayares,Michael Mendicino,Kevin Wells,Amy Dandro
申请号：
US13092242
公开号：
US20120090039A1
申请日:
2011.04.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Porcine animals, tissue and organs as well as cells and cell lines derived from such animals are provided that lack functional endogenous immunoglobulin loci and are deficient in immunoglobulin expression and B-cells. These animals are useful as model systems for research and for development of new pharmaceutical and biological agents. In addition, methods are provided to prepare such animals.
