Combination therapy for the treatment of obesity and diabetes, and conditions associated therewith, and for the treatment of conditions that are alleviated by increasing blood GLP-1 levels

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专利权人:

ファーマシューティカルズ，;インコーポレイテッド;アリーナ ファーマシューティカルズ, インコーポレイテッド;アリーナ

发明人:

チュー， チ－リヤン,レオナード， ジェームス エヌ．,チュー, チ-リヤン,レオナード, ジェームス エヌ.

申请号：

JP2008509119

公开号：

JP5774264B2

申请日:

2006.04.26

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention concerns combination of an amount of a BRS-3 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the BRS-3 agonist alone and by the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing obesity and diabetes and conditions related thereto and conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/