ALBERATI DANIELA,MOREAU JEAN-LUC,WETTSTEIN JOSEPH G.
申请号：
NZ60489111
公开号：
NZ604891A
申请日:
2011.08.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a pharmaceutical combination comprising an atypical antipsychotic drug and a glycine transporter inhibitor GlyT1 receptor antagonist of formula (I). An examples of a compound of formula (I) is [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone (also known as Bitopertin or RG1678). Examples of an atypical antipsychotic drug are risperidone, paliperidone, olanzapine, aripiprazole, quetiapine and ziprasidone. The compounds are useful in the treatment of positive and negative symptoms in schizophrenia.
