A drug carrying cell penetrating molecule (DCCPM) comprising: a biologically active compound (BAC), and a cell penetrating agent (CPA), which BAC and CPA are linked directly or via a bi-functional linker (BFL), and wherein the CPA is a stabilized peptide (CPP). The peptide may be stabilized by i) stapling two amino acids to form Stapled CPP's (StaP's) or ii) stitching three or more amino acids to form stitched CPP's (StiP's). These stabilized CPP's are conjugated to a drug or Biologically Active Compound (BAC) so that the BAC can be carried though a cell membrane by the CPP. The preferred BAC is an electrically low charge carrying oligonucleotide such as a phosphorodiamate morpholino-oligonucleotide (PMO). The use of a DCCPM in a treatment of a disease requiring alteration of an endogenous or exogenous gene, a method of improving the bioavailability of a drug or BAC, a method of introducing a drug or BAC to a site which is refractory to the drug or BAC in its native state is claimed.
