An exemplary surgical method of treating tissue within the body of a patient, may include providing an endocutter having a knife, a staple holder along which the knife is slidable, feeder belts located on each side of the knife, staples having a first size, those staples integral with and breakable from at least one feeder belt, and staples having a second size different from the first size, those staples integral with and breakable from at least one feeder belt； engaging tissue of the patient with the staple holder； deploying at least two staples having a first size； disengaging tissue of the patient from the staple holder； once again engaging tissue of the patient with the same staple holder； and deploying at least two staples having a second size.
