METHOD OF REGULATING THE CIRCADIAN RHYTHM OF AN INDIVIDUAL COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF A CIRCADIAN RHYTHM REGULATOR CONTAINING 1,2-DI-O-GALLOYL-4,6-O-(S)-HEXAHYDROXYDIPHENOYL-B-D-GLUCOSE
This invention provides a new application to 1,2-di-O-galloyl-4,6-O—；(S)-hexahydroxydiphenoyl-ß-D-glucose (i.e. GHG) that is contained in Kenyan purple tea (scientific name: Camellia sinensis； variety name: TRFK306), as well as a new circadian-rhythm regulator that can be widely used in medicines, foods and drinks, and cosmetics. The circadian-rhythm regulator of this invention is characterized in containing the GHG as an active ingredient for promoting the BMAL1 gene-expression. Also, the circadian-rhythm regulator of this invention is characterized in containing the GHG-content extract derived from Kenyan purple tea as an active ingredient for promoting the BMAL1 gene-expression.
