The U.S.A.; as represented by the Secretary; Department of Health and Human Services
发明人:
Peter Kwong,Marie Pancera,Tongqing Zhou,Ivelin Georgiev,Michael Gordon Joyce,Priyamvada Acharya,Jason Gorman,Yongping Yang,Guillaume Stewart-Jones,Rita Chen,Gwo-Yu Chuang,John Mascola,Baoshan Zhang,Ch
申请号：
US16557894
公开号：
US20190389915A1
申请日:
2019.08.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.
