PURPOSE: A composition containing novel chalcone compound pyrazolylnaphthalenol derivatives for preventing and treating cardiovascular diseases is provided to suppress MAO-A(monoamine oxidase)-A.CONSTITUTION: A novel chalcone compound pyrazoylynaphthalenol derivative is denoted by chemical formula 1. The derivative is 1-(1-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)naphthalen-2-ol. The derivative suppresses MAO-A. A method for preparing the derivative comprises: a step of reacting 2-hydroxy-1-acetonaphthone and 4-trimethoxybenzaldehyde under the presence of a base to prepare a chalcone compound, 4,5-benzo-1-hydroxy-4`-methoxycalcone and a step of reacting the chalcone compounds with 4-fluorophenylhydrazine to prepare pyrazoylylnaphthalenol derivative 1-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dehydro-1H-pyrazole-3-yl-naphthalene-2-ol. A pharmaceutical composition for preventing and treating cardiovascular diseases contains the derivative or a pharmaceutically acceptable salt thereof as an active ingredient.COPYRIGHT KIPO 2013본 발명은 모노아민옥시다제-A의 저해 활성을 갖는 신규한 칼콘 화합물 피라졸릴나프탈레놀 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 심혈관계 질환의 예방 및 치료용 조성물에 관한 것으로, 본 발명의 신규한 칼콘 화합물 피라졸릴나프탈레놀 유도체는 우수한 MAO-A 저해 활성을 나타내기 때문에 심혈관 질환을 예방 및 치료하는데 유용하게 사용될 수 있다.
