#$%^&*AU2015213373A120150903.pdf#####-73 ABSTRACT It was revealed that the intravenous administration of HMGB- and S1 OA promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGBl-I was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in Mice intravenously administered with H-MGB-i as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB--1 administration group. The involvement of bone marrow pluripotent stem cells in the process ofbone fracture heanlig was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.
