SUN, CECILY R.Y.,SUN, BILL N. C.,FUNG, MICHAEL S.C.
申请号：
CA2424379
公开号：
CA2424379C
申请日:
2001.10.04
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to C5 inhibitors, whic inhibit type II edothelial cell activation, wehrein the inhibition is manifested by the suppresion of E-selectin. These inhibitors are useful in treatment of delayed xenograft rejection or acute vascular rejection. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immnoglobulin fragments like Fab, F(ab')2 and Fv, small molecules, including peptides, oligonucleotides, peptidominetics and organic compounds. Examples of monoclonal antibodies, which bind to and inhibit C5, were generated and are designated MAb 137-76 and MAb 137-30.
