您的位置: 首页 > 农业专利 > 详情页

METHOD FOR MANUFACTURING MEDICINAL COMPOUNDS CONTAINING DABIGATRAN
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
RADTKE, GUIDO BERNHARD EDMUND
申请号:
NZ58974609
公开号:
NZ589746A
申请日:
2009.07.13
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein is a process for preparing a suspension of the polymorph I of the methanesulphonic acid salt of dabigatran etexilate of formula I, characterised in that the polymorph I of dabigatran etexilate methanesulphonate being characterised by a melting point of 180°C ± 3°C (determined by DSC heating rate: 10°C/min) is suspended together with talc in a solution of hydroxypropylcellulose in isopropyl alcohol, the preparation of the suspension being carried out at a temperature not exceeding 30°C by the circulatory dispersal process, wherein a dispersion device is connected to a batch container and the isopropyl alcohol is circulated through the batch container to generate a suction vacuum to suck in the hydroxypropylcellulose, the polymorph I of dabigatran etexilate methanesulphonate and the talc..
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充