The present invention relates to conjugates of hydroxyalkyl starch, preferably hydroxyethyl starch, and a protein, wherein these conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. The present invention also relates to the method of producing these conjugates and specific uses of the conjugates.本發明係關於羥基烷基澱粉，宜為羥基乙基澱粉，與蛋白質之接合體，其中，此等接合體係藉著羥基烷基澱粉或羥基烷基澱粉衍生物之至少一個醛基基團或酮基基團或半縮酮基團與蛋白質之至少一個胺基間進行還原性胺化作用，使得羥基烷基澱粉或其衍生物經由甲亞胺鍵聯或胺基鍵聯共價地連接到蛋白質上而形成。本發明亦關於製造此等接合體的方法及接合體之特定用途。
