The base substance, the especially medical application device, being, biology mimetic method in order coating to do with the biology mimetic composition: The method at closed system of producing the biology mimetic composition which a) calcium and magnesium, includes phosphoric acid, the carbonic acid hydrion and the brine blend which includes the bioactive substance and is acidified, with batch system, b) making the aforementioned base substance the aforementioned biology mimetic composition contact, c) aforementioned biology mimetic composition contact making with the aforementioned base substance and storing, putting in a state where the increase which pH will be slow is possible, also precipitation and aforementioned bioactive substance of the salt making precipitation cause on the aforementioned base substance, obtaining the base substance which coating is done, including process.< Selective figure >It is not基体、特に医療用装置を、バイオミメティック組成物でコーティングするための、バイオミメティック方法であって:a) カルシウム、マグネシウム、リン酸、炭酸水素イオンおよび生理活性物質を含む食塩水混合物を含む酸性化されたバイオミメティック組成物を、閉鎖系にてバッチ式で作製し、b) 前記基体を前記バイオミメティック組成物に接触させ、c) 前記バイオミメティック組成物を前記基体と接触させて貯蔵し、pHのゆっくりとした増加が可能な状態とし、前記基体上に塩の沈殿および前記生理活性物質の共沈殿を生じさせ、コーティングされた基体を得る、工程を含む方法。【選択図】なし
