This document discusses, among other things, systems and methods for programming a neuromodulation therapy to treat neurological or cardiovascular diseases. A system includes an ambulatory medical device (AMD) and at least one computer-readable storage medium including instructions executable on an external system. The instructions, when executed by the external system, causes a user interface in the external system to receive a waveform function and one or more modulation parameter values. The waveform function includes one or more modulation programs characterized by one or more modulation parameters. The instructions causes a compiler to translate the waveform function into virtual machine (VM) instructions, which can be transmitted to the AMD. The AMD includes a VM that executes the VM instructions, and generates one or more modulation waveform datasets. The AMD may generate and deliver electrostimulation therapy in accordance with the one or more modulation waveform datasets.
