Oligomer-specific amyloid beta epitope and antibodies

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专利权人:

The University of British Columbia

发明人:

Cashman, Neil R.

申请号：

AU2016208334

公开号：

AU2016208334A1

申请日:

2016.07.27

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016208334A120160811.pdf#####ABSTRACT A novel constrained peptide epitope derived from AP, related antibody compositions and methods of use. An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric As is described. An antigenic peptide comprising an epitope having a constrained cyclic configuration, corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric A is also described. Methods of treating, preventing, and diagnosing Alzheimers disease are also described.

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