Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
Ravi V. J. Chari;Walter A. Blättler;Rita M. Steeves
发明人:
Rita M. Steeves,Ravi V. J. Chari,Walter A. Blättler
申请号:
US10960602
公开号:
US08088387B2
申请日:
2004.10.08
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.