HAUSMANN JUERGEN,MEISINGER HENSCHEL Christine,SUTER MARK
申请号：
IN6135/DELNP/2012
公开号：
IN2012DN06135A
申请日:
2012.07.10
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
THE PRESENT INVENTION PROVIDES METHODS OF PRODUCING MODIFIED VACCINIA VIRUS (VACV) GENOMES AND RELATED VECTORS. THE METHOD CONSISTS ESSENTIALLY IN DELETING ONE OR MORE OF THE VACCINIA GENOMIC REGIONS CORRESPONDING TO THOSE THAT ARE PRESENT IN THE CHORIOALLANTOIS VACCINIA VIRUS BUT ABSENT IN THE MODIFIED VACCINIA ANKARA VIRUS. THE RESULTING VIRUSES, VECTORS AND HOST CELLS ARE ALSO DISCLOSED. MOREOVER, A METHOD FOR DETERMINING THE EFFECT OF A MUTATION ON A VACCINIA VIRUS, USING ONE OF THE MODIFIED VACCINIA VIRUSES OF THE INVENTION, IS ALSO CONTEMPLATED.
