The Board of Trustees of the Leland Stanford Junior University
发明人:
Karl A. Deisseroth,Soo Yeun Lee,Charu Ramakrishnan,Andre Berndt
申请号：
US16057639
公开号：
US10478499B2
申请日:
2018.08.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.
