Dúplex oligonucleotídicos que comprenden nucleótidos de tipo ADN y de tipo ARN y usos de los mismos

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专利权人:

Paladin Labs Inc.

发明人:

DAMHA, Masad J.,WATTS, Jonathan K.,DELEAVEY, Glen

申请号：

ES09757018

公开号：

ES2643576T3

申请日:

2009.06.05

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2&prime-sub-stituted arabinonucleotides (ANA)) in combination with one or more RNA-like nucleotides (e.g., 2&prime-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.

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