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PRODUIT EN GEL INJECTABLE
专利权人:
NESTLE SKIN HEALTH SA
发明人:
OHRLUND, AKE,KARLSSON, MORGAN
申请号:
CA3086428
公开号:
CA3086428A1
申请日:
2018.12.18
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The present invention provides a method of producing an injectable gel product, comprising the steps of a) cross-linking a first glycosaminoglycan (GAG) with a first crosslinking agent to produce a gel, wherein the charging ratio of crosslinking agent to disaccharide unit is below 0.15; b) preparing particles of the gel from step a); c) mixing the glycosaminoglycan (GAG) gel particles of step b) with a second glycosaminoglycan (GAG) to provide a mixture; d) cross-linking the mixture of step c) with a second crosslinking agent to obtain cross-linking between the glycosaminoglycans (GAGs) of the second, outer phase, thereby providing a gel having a first, inner phase of the cross-linked glycosaminoglycan (GAG) gel particles, embedded in a gel of the second, outer phase comprising the second glycosaminoglycan (GAG), and e) preparing injectable particles of the gel from step d), each such particle containing a plurality of the cross-linked GAG gel particles of the first, inner phase. The present invention further provides an injectable gel product, an aqueous composition, and a pre-filled syringe.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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