TNFRSF-BINDING AGENTS AND USES THEREOF

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专利权人:

发明人:

Austin L. GURNEY

申请号：

US15014134

公开号：

US20160256527A1

申请日:

2016.02.03

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising GITRL, OX40L, or CD40L and/or bispecific agents. Also disclosed are methods of using the polypeptides or agents for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.

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