A connection clamping device (21 61 81 131 151) arranged for connecting a flexible tube (1) to a barbed end (5b) of a connection means (5), whereby the barbed end (5b) comprises a barb (9) and the connection means during connection is arranged to protrude into an end of the flexible tube (1), characterized in that said connection clamping device comprises two halves (23a, 23b) which, during connection when the connection means protrudes into an end of the flexible tube, are arranged to be connected and locked to each other by a locking mechanism (33a,33b,34a,34b 63a, 63b, 64a, 64b) around the connection means (5) and the flexible tube (1), such that the flexible tube (1) is compressed against the connection means (5) by a rib (41a, 41b) provided on the inner circumference of the connection clamping device.