TRABANCO-SUAREZ, Andrés Avelino,GIJSEN, Henricus Jacobus Maria,VAN GOOL, Michiel Luc Maria,VEGA RAMIRO, Juan Antonio,DELGADO-JIMENEZ, Francisca
申请号：
ES12707276
公开号：
ES2558779T3
申请日:
2012.02.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula (I) ** Formula ** or one of its tautomers or one of its stereoisomeric forms, wherein R1 and R2 are independently selected from the group consisting of hydrogen, halo, cyano, C1-3 alkyl, mono- and polyhalo (C1-3) alkyl and C3-6 cycloalkyl； R3 is selected from the group consisting of hydrogen, C1-3 alkyl, C3-6 cycloalkyl, mono- and polyhalo-C1-3 alkyl homoaryl and heteroaryl； X1, X2, X3, X4 are independently C (R4) or N, with the proviso that no more than two of them represent N； each R4 is selected from the group consisting of hydrogen, halo, C1-3 alkyl, mono- and polyhalo-C1-3 alkyl, cyano, C1-3 alkyloxy, mono- and polyhalo-C1-3 alkyloxy； L is a bond or -N (R5) CO-, wherein R5 is hydrogen or C1-3 alkyl； Ar is homoaryl or heteroaryl； wherein the homoaryl is phenyl or phenyl substituted with one, two or three substituents selected from the group consisting of halo, cyano, C1-3 alkyl, C1-3 alkyloxy, mono- and polyhalo-C1-3 alkyl, mono- and polyhalo-C1-3 alkyloxy； The heteroaryl is selected from the group consisting of pyridyl, pyrimidyl, piracyl, pyridacyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, thiadiazolyl, oxazolyl and oxadiazolyl, each optionally substituted with one, two or three substituents selected from the group consisting of halo, cyano, C1-3 alkyl, C1-3 alkyloxy, mono- and polyhalo-C1-3 alkyl, mono- and polyhalo-C1-3 alkyloxy； or one of its salts by addition or one of its solvates.Un compuesto de Fórmula (I)**Fórmula** o uno de sus tautómeros o una de sus formas estereoisómeras, en donde R1 y R2 se seleccionan independientemente del grupo que consiste en hidrógeno, halo, ciano, alquilo C1-3, mono- y polihalo-alquilo(C1-3) y cicloalquilo C3-6； R3 se selecciona del grupo que consiste en hidrógeno, alquilo C1-3, cicloalquilo C3-6, mono- y polihalo-alquilo(C1-3) homoarilo y heteroarilo； X1, X2, X3, X4 son independientemente C(R4) o N, con la condición de que no más de dos de ellos representen N； cada R4 se
